Lengacher, C., et al. (2009). Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer. (Abstract). Psycho-Oncology. Click for full article.
Objectives: Considerable morbidity persists among survivors of breast cancer (BC) including high levels of psychological stress, anxiety, depression, fear of recurrence, and physical symptoms including pain, fatigue, and sleep disturbances, and impaired quality of life. Eﬀective interventions are needed during this diﬃcult transitional period.
Methods: We conducted a randomized controlled trial of 84 female BC survivors (Stages 0–III). All subjects were within 18 months of treatment completion with surgery and adjuvant radiation and/or chemotherapy. Subjects were randomly assigned to a 6-week Mindfulness-Based Stress Reduction (MBSR) program designed to self-regulate arousal to stressful circumstances or symptoms (n 541) or to usual care (n 543). Outcome measures compared at 6 weeks by random assignment included validated measures of psychological status (depression, anxiety, perceived stress, fear of recurrence, optimism, social support) and psychological and physical subscales of quality of life.
Results: Compared with usual care, subjects assigned to MBSR(BC) had signiﬁcantly lower levels of depression, anxiety, and fear of recurrence at 6 weeks, along with higher energy, physical functioning , and physical role functioning. In stratiﬁed analyses, subjects more compliant with MBSR tended to experience greater improvements in measures of energy and physical functioning.
Conclusions: Among BC survivors within 18 months of treatment completion, a 6-week MBSR(BC) program resulted in signiﬁcant improvements in psychological status and quality of life compared with usual care.
© 2009 John Wiley & Sons, Ltd.